microtubule-associated protein 10; microtubule regulator of 120 KD (MAP10, KIAA1383, MTR120)

Function

• microtubule-associated protein (MAP)
• role in the regulation of cell division
• promotes microtubule stability
• participates in the organization of the spindle midzone & normal progress of cytokinesis
• interacts (via middle region) with microtubules

Compartment

• cytoplasm, cytoskeleton
• spindle pole, microtubule organizing center
• centrosome, midbody
• localized at stabilized microtubules during interphase & to the mitotic apparatus during mitosis
• localized at spindle poles in metaphase & spindle midzone during telophase
• colocalized with polo-like kinase PLK1 to the center of spindle midzone
• localized at the midbody during cytokinesis
• colocalized with acetylated-tubulin at microtubules

Expression

• expressed in different cell lines (at protein level)

More general terms

• other protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54627
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54627
• UniProt: http://www.uniprot.org/uniprot/Q9P2G4.html