APC membrane recruitment protein 2; Amer2; protein FAM123A (AMER2, FAM123A)

Function

• negative regulator of canonical Wnt signaling pathway involved in neuroectodermal patterning
• specifically binds phosphatidylinositol 4,5-bisphosphate (Ptdins(4,5)P2), translocating to the cell membrane & interacting with key regulators of Wnt signaling, such as components of the beta-catenin destruction complex
• interacts with APC

Structure

belongs to the Amer family

Compartment

• cell membrane
• translocates to the cell membrane following binding to Ptdins(4,5)P2

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=219287
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:219287
• OMIM: https://mirror.omim.org/entry/614659
• UniProt: http://www.uniprot.org/uniprot/Q8N7J2.html