BMP/retinoic acid-inducible neural-specific protein 3; DBCCR1-like protein 1 (BRINP3, DBCCR1L, DBCCR1L1, FAM5C)

Function

• inhibits neuronal cell proliferation by negative regulation of the cell cycle transition
• promotes pituitary gonadotrope cell proliferation, migration & invasion, when overexpressed

Structure

• belongs to the BRINP family
• contains 1 MACPF domain

Compartment

• secreted (putative)
• mitochondria

Expression

• strongly expressed in oral keratinocytes
• weak expression in tongue squamous cell carcinoma
• expressed in endothelial & aortic smooth muscle cells
• overexpressed in gonadotropinomas

Pathology

• may play a role in cell pituitary tumor development

More general terms

• secreted protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=339479
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:339479
• UniProt: http://www.uniprot.org/uniprot/Q76B58.html