BMP/retinoic acid-inducible neural-specific protein 1; deleted in bladder cancer protein 1 (BRINP1, DBC1, DBCCR1, FAM5A, IB3089A)

Function

• inhibits cell proliferation by negative regulation of the G1/S transition
• mediates cell death
  • not classical apoptosis
• regulates expression of components of the plasminogen pathway

Structure

• belongs to the BRINP family
• contains 1 MACPF domain

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

• expressed in brain > heart, lung, skeletal muscle, kidney, thymus, prostate, testis, small intestine

Pathology

• gene deleted in bladder cancer (transitional cell carcinoma)
• silenced by methylation in 50% of bladder cancer cell lines

More general terms

• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1620
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1620
• OMIM: https://mirror.omim.org/entry/602865
• UniProt: http://www.uniprot.org/uniprot/O60477.html