irradiation of cellular blood products

Indications

Prevention of graft versus host disease (GVHD)

• well established risk
  • recipeints of allogeneic or autologous bone marrow transplant or stem cell transplants
  • patients receiving aggressive chemotherapy &/or radiation therapy
  • transfusions from blood relatives
  • HLA-matched platelet transfusions
  • congenital immunodeficiency syndromes
  • premature infants
  • intrauterine transfusions
  • neonatal exchange transfusions
• risk less well established
  • recipients of solid organ transplants
    • nearly all cases of GVHD are caused by engraftment of lymphocytes from the donor organ rather than from blood products
  • HIV infection
    • transfusion associated GVHD has not been reported in patients with AIDS

Additional terms

• blood products
• blood transfusion
• electromagnetic radiation