plasminogen deficiency

Classification

• type 1:
  • decreased plasminogen activity in plasma
  • decreased plasminogen antigen in plasma
  • clinical symptoms
• type 2
  • normal or slightly decreased plasminogen antigen in plasma
  • asymptomatic

Pathology

• type 1:
  • markedly impaired extracellular fibrinolysis
  • chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition & inflammation

Genetics

• associated with defects in plasminogen

Clinical manifestations

• type 1:
  • ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa
• type 2: asymptomatic

Laboratory

• decreased serum plasminogen activity
• plasminogen antigen in plasma may be normal or decreased

More general terms

• blood protein disorder
• enzyme deficiency
• hypercoagulability
• genetic disease of the blood/bone marrow

Additional terms

• plasminogen; contains: plasmin heavy chain A; activation peptide; angiostatin; plasmin light chain B (PLG)

Database

• OMIM: https://mirror.omim.org/entry/217090