pepsin A-5; pepsinogen-5 (PGA5)
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Function
- shows particularly broad specificity
- preferential cleavage: hydrophobic, preferably aromatic, residues in P1 & P1' positions
- cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 & 25-Phe-|-Tyr-26 bonds in the B chain of insulin
Structure
belongs to the peptidase A1 family