pepsin A-4; pepsinogen-4 (PGA4)

Function

• shows particularly broad specificity
  • bonds involving Phe & Le are preferred
    • many others are also cleaved to some extent
• preferential cleavage: hydrophobic, preferably aromatic, residues in P1 & P1' positions. cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 & 25-Phe-|-Tyr-26 bonds in the B chain of insulin

Structure

belongs to the peptidase A1 family

Compartment

secreted

More general terms

• pepsin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=643847
• OMIM: https://mirror.omim.org/entry/169700
• OMIM: https://mirror.omim.org/entry/169720
• UniProt: http://www.uniprot.org/uniprot/P0DJD7.html