Philadelphia chromosome-positive chronic myeloid leukemia (CML)
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Epidemiology
- 90% of chronic myeloid leukemia (CML)
Genetics
- chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome)
- a truncated c-abl is translocated from chromosome 9 to the bcr locus on chromosome 22
- the breakpoint on chromosome 9 ranges from 15-40 kb upstream from the first exon of the abl gene
- breakpoints on chromosome 22 occur over ~5-6 kb referred to as the breakpoint cluster region (M-bcr) which contains exons 1-3 of the bcr gene
More general terms
Additional terms
- abl proto-oncogene
- breakpoint cluster region protein P160 (p160BCR)
- chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome; bcr/abl)