xylazine (Xyla-Ject, TranquiVed, AnaSed, XylaMed, tranq)
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Introduction
Used in veterinary medicine.
Added to street fentanyl* to boost its effects & extend its high[2]
* not for human use[2]
Indications
Adverse effects
- severe necrotic wounds, may extend to bone[2][4]*
- amputation
* image[4]
- drug adverse effects of adrenergic receptor agonists
- drug adverse effects of alpha-adrenergic receptor agonists
- drug adverse effects of sympathomimetic(s)
More general terms
References
- ↑ Wikipedia: Xylazine http://en.wikipedia.org/wiki/Xylazine
- ↑ 2.0 2.1 2.2 2.3 Fiore K What Doctors Should Know About Xylazine in Fentanyl. Naloxone still works but additional support may be needed; wound care a challenge. MedPage Today February 1, 2023 https://www.medpagetoday.com/special-reports/features/102915
- ↑ D'Orazio J, Nelson L, Perrone J et al Xylazine Adulteration of the Heroin-Fentanyl Drug Supply. A Narrative Review. Ann Intern Med. 2023. Oct 10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37812779 https://www.acpjournals.org/doi/full/10.7326/M23-2001
- ↑ 4.0 4.1 4.2 Gupta R, Holtgrave DR, Ashburn MA. Xylazine - Medical and Public Health Imperatives. N Engl J Med 2023; 388:2209-2212 PMID: https://www.ncbi.nlm.nih.gov/pubmed/3709933 https://www.nejm.org/doi/10.1056/NEJMp2303120
- ↑ Kariisa M, O'Donnell J, Kumar S, Mattson CL, Goldberger BA. Illicitly Manufactured Fentanyl-Involved Overdose Deaths with Detected Xylazine - United States, January 2019-June 2022. MMWR Morb Mortal Wkly Rep 2023;72:721-727 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37384558 PMCID: PMC10328484 Free PMC article https://www.cdc.gov/mmwr/volumes/72/wr/mm7226a4.htm