G antigen 12I; GAGE-12I (GAGE12I)
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Structure
- forms tetramers (putative)
- belongs to the GAGE family
Alternative splicing
named isoforms=2
Expression
- restricted to germ cells
Genetics
- belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells
- these genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
- their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T cells
More general terms
References
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100008
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2579
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26748
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=645073
- UniProt: http://www.uniprot.org/uniprot/P0CL82.html