G antigen 12G; GAGE-12G (GAGE12G)

Structure

• forms tetramers (putative)
• belongs to the GAGE family

Alternative splicing

named isoforms=2

Expression

• restricted to germ cells

Genetics

• belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells
• these genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
• their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T cells

More general terms

• GAGE protein (G antigen family)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100008
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2579
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26748
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=645073
• UniProt: http://www.uniprot.org/uniprot/P0CL81.html