G antigen 12G; GAGE-12G (GAGE12G)

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Structure

Alternative splicing

named isoforms=2

Expression

Genetics

  • belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells
  • these genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
  • their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T cells

More general terms

References

Database