endometrial dysplasia/hyperplasia

Etiology

• unopposed estrogen in women taking hormone replacement therapy increase risk
• tamoxifen increases endometrial hyperplasia

Clinical manifestations

• abnormal uterine bleeding (most common presenting symptom)

Laboratory

• endometrial biopsy for atypia

Diagnostic procedures

• pelvic ultrasound for endometrial thickness

Complications

• endometrial carcinoma
• dysfunctional uterine bleeding

Management

• endometrial hyperplasia without atypia responds well to progestins
• hysterectomy for women with atypia, unless contraindicated

More general terms

• epithelial dysplasia
• uterine disease

Additional terms

• endometrium