human anti-mouse antibody (HAMA)

Etiology

• administration of mouse monoclonal antibody to human

Epidemiology

• 1/3 of patients receiving mouse monoclonal antibody
• 10% of population carries some anti-animal antibody
• newer in-vitro techniques manufacture monoclonal antibodies without use of mice, thus new cases becoming a relic of the past

Clinical manifestations

• variable
• rash
• renal failure

Laboratory

• diagnostic reagents that use mouse antibodies may not function properly

More general terms

• sign/symptom