primary juvenile lateral sclerosis

Introduction

closely related to but clinically distinct from amyotrophic lateral sclerosis.

Epidemiology

rare

Pathology

• progressive paralytic disorder resulting from upper motor neuron disease with lower motor neurons unaffected

Genetics

• associated with mutations in the gene for alsin

More general terms

• amyotrophic lateral sclerosis (ALS); Lou Gerig's disease
• genetic disease of the central nervous system

Additional terms

• alsin; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; amyotrophic lateral sclerosis 2 protein (ALS2 ALS2CR6 KIAA1563)

Database

• OMIM: https://mirror.omim.org/entry/606353