FLT3 gene mutation

Clinical significance

• somatic mutations leading to constitutive activation of FLT3 are a cause of acute myeloid leukemia (AML)
  • mutations fall into two classes
    • the most common is in-frame internal tandem duplications of variable length in the juxtamembrane region that disrupt the normal regulation of kinase activity
    • point mutations in the kinase domain can result in a constitutively activated kinase

More general terms

• gene mutation testing; gene mutation analysis

Additional terms

• FL cytokine receptor; tyrosine-protein kinase receptor FLT3; stem cell tyrosine kinase 1; STK-1; CD135 (FLT3, STK1)