small proline-rich protein 2D; SPR-2D; small proline-rich protein II; SPR-II (SPRR2D)

Function

• cross-linked envelope protein of keratinocytes
• keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase; this results in the formation of an insoluble envelope beneath the plasma membrane

Structure

belongs to the cornifin (SPRR) family

Compartment

cytoplasm

Expression

• expressed during squamous differentiation of epidermal keratinocytes

More general terms

• small proline-rich protein 2

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6703
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6703
• UniProt: http://www.uniprot.org/uniprot/P22532.html