Lisch nodule
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Introduction
pigmented hamartomatous nevus affecting the iris, named after Austrian ophthalmologist Karl Lisch (1907-1999), who described them in 1937
Etiology
- found in patients with neurofibromatosis type 1
Pathology
- clear, yellow-brown, oval to round, dome-shaped papules that project from the surface of the iris
- nodules generally do not affect vision
- nodules stain positive for vimentin & S-100
- likely of ectodermal origin
Diagnostic procedures
- nodules etected by slit lamp examination