CDw217; interleukin-17 receptor A; IL-17 receptor; CD217 (IL17RA, IL17R)

Function

• receptor for IL17A
• binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling

Structure

glycosylated

Compartment

membrane

Expression

widely expressed

Pathology

• appears to play a role in psoriasis

Pharmacology

• IL17A receptor antibody (brodalumab) is effective in treatment of psoriasis

More general terms

• CD antigen
• interleukin-17 receptor (IL17R)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2376
• OMIM: https://mirror.omim.org/entry/605461
• UniProt: http://www.uniprot.org/uniprot/Q96F46.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23765