chromosomal translocation t(2;22)(q33;q12)

Introduction

• translocation t(2;22)(q33;q12) involving EWSR1 with CREB1 is a cause of angiomatoid fibrous histiocytoma.
  • translocation generates a EWSR1/CREB1 fusion gene
  • most common genetic abnormality in angiomatoid fibrous histiocytoma

More general terms

• chromosomal translocation

Additional terms

• cAMP-responsive element [CRE]-binding protein 1 (CREB1)
• RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein (EWSR1, EWS)