glucarpidase (Voraxaze)
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Indications
- treatment of methotrexate toxicity due to renal failure
Dosage
- intravenous administration
Pharmacokinetics
- methotrexate levels fall below critical levels in 15 minutes
- 95% of methotrexate is eliminated
Adverse effects
Mechanism of action
- rapidly reduces methotrexate levels via metabolism to a form that can be eliminated in patient
More general terms
References
- ↑ FDA NEWS RELEASE: Jan. 17, 2012 FDA approves Voraxaze to treat patients with toxic methotrexate levels http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm287997.htm