17-hydroxyprogesterone in serum/plasma

Indications

• evaluation of congenital adrenal hyperplasia
• evaluation of corpus luteum contribution of progestational activity during pregnancy

Reference interval

• premature infant: 26-568 ng/dL
• newborn 7-77 ng/dL
• prepubertal children : 3-90 ng/dL
• adults: 27-199 ng/mL
• pregnancy: 200-1200 ng/dL
• postmenopause: < 70 ng/dL

Clinical significance

• 17-hydroxyprogesterone has a circadian variation with highest serum values in the AM
• leuteal phase variation indicates corpus luteum activity

Increases

• congenital adrenal hyperplasia from 21-hydroxylase deficiency

Decreases

• male pseudohemophrodism
• Addison's disease

Methods

• RIA

Specimen

• early morning specimen preferred
• freeze immediately
• store at 4 degrees C for up to 4 days

More general terms

• 17-hydroxyprogesterone in body fluid

Additional terms

• 17-hydroxyprogesterone (Duralutin, Makena, Prodrox)