golimumab (Simponi)
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Indications
- for use in combination with methotrexate for treatment of rheumatoid arthritis[4][5]
- psoriatic arthritis[4]
- ankylosing spondylitis[4]
- ulcerative colitis[3]
Contraindications
Dosage
- injection, 50 mg SC monthly
Monitor
- screening for tuberculosis[4]
- CBC, LFTs, serum creatinine at baseline & every 3-6 months thereafter[4]
Adverse effects
- risk of serious fungal infections, including histoplasmosis
- drug adverse effects of immunosuppressive agents
- drug adverse effects of tumor necrosis factor (TNF) inhibitors
- drug adverse effects of biologic immunosuppressive agents
Laboratory
Mechanism of action
Notes
- cost about $1500 a month (2009)
More general terms
References
- ↑ FDA MedWatch - Simponi (golimumab)-Risk of serious fungal infections associated with TNF-?lpha blockers, including Simponi http://www.fda.gov/medwatch/safety/2009/safety09.htm#Simponi
- ↑ Prescriber's Letter 16(6): 2009 Simponi (Golimumab): A Monthly Injectable Drug for Arthritis PATIENT HANDOUT: What I Need to Know About My Rheumatoid Arthritis Medication GUIDELINES: Use of Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250603&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 3.0 3.1 FDA News Release: May 15, 2013 FDA approves Simponi to treat ulcerative colitis http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm352383.htm
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Medical Knowledge Self Assessment Program (MKSAP) 16, 17, 18, 19. American College of Physicians, Philadelphia 2012, 2015, 2018, 2022.
- ↑ 5.0 5.1 Singh JA, Noorbaloochi S, Singh G. Golimumab for rheumatoid arthritis: a systematic review. J Rheumatol. 2010 Jun;37(6):1096-104 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20436075