golimumab (Simponi)

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Indications

Contraindications

Pregnancy category: B[4]

Dosage

  • injection, 50 mg SC monthly

Monitor

Adverse effects

Laboratory

Mechanism of action

Notes

  • cost about $1500 a month (2009)

More general terms

References

  1. FDA MedWatch - Simponi (golimumab)-Risk of serious fungal infections associated with TNF-?lpha blockers, including Simponi http://www.fda.gov/medwatch/safety/2009/safety09.htm#Simponi
  2. Prescriber's Letter 16(6): 2009 Simponi (Golimumab): A Monthly Injectable Drug for Arthritis PATIENT HANDOUT: What I Need to Know About My Rheumatoid Arthritis Medication GUIDELINES: Use of Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=250603&pb=PRL (subscription needed) http://www.prescribersletter.com
  3. 3.0 3.1 FDA News Release: May 15, 2013 FDA approves Simponi to treat ulcerative colitis http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm352383.htm
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Medical Knowledge Self Assessment Program (MKSAP) 16, 17, 18, 19. American College of Physicians, Philadelphia 2012, 2015, 2018, 2022.
  5. 5.0 5.1 Singh JA, Noorbaloochi S, Singh G. Golimumab for rheumatoid arthritis: a systematic review. J Rheumatol. 2010 Jun;37(6):1096-104 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20436075