alternative antiviral regimens for HIV treatment failure
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Introduction
Initial regimen: zidovudine (AZT) + didanosine (ddI)
Alternative combinations:
- AZT + 3TC + protease inhibitor
- d4T + 3TC + protease inhibitor
- ritonavir + saquinavir + NRTI*
Initial regimen: zidovudine (AZT) + zalcitabine (ddC)
Alternative combinations:
- AZT + 3TC + protease inhibitor
- d4T + 3TC + protease inhibitor
- d4T + ddI + protease inhibitor
- ritonavir + saquinavir + NRTI*
, Initial regimen: zidovudine (AZT) + lamivudine (3TC)
Alternative combinations:
- d4T + ddI + protease inhibitor
- ritonavir + saquinavir + NRTI*
Initial regimen: stavudine (d4T) + didanosine (ddI)
Alternative combinations:
- AZT + 3TC + protease inhibitor
- ritonavir + saquinavir + NRTI*
Initial regimen: stavudine (d4T) + lamivudine (3TC)
Alternative combinations:
- AZT + ddI + protease inhibitor
- ritonavir + saquinavir + NRTI*
* Nucleoside Reverse Transcriptase Inhibitor
Continued treatment benefits even those with persistent viremia despite 3 drug therapy[2]
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ 2.0 2.1 The PLATO Collaboration: Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes. Lancet 364:51, 2004 http://www.thelancet.com/journal/vol363/iss9417/full/llan.364.9428.primary_research.30149.1