nuclear envelope pore membrane protein POM 121C; pore membrane protein of 121 kD; nuclear pore membrane protein 121-2; POM121-2 (POM121C)

Function

• essential component of the nuclear pore complex (NPC)
• the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane
• when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL)

Structure

• contains F-X-F-G repeats
• belongs to the POM121 family

Compartment

• nucleus, nuclear pore complex, nucleus membrane
• endoplasmic reticulum membrane
• stably associated with the nuclear pore complex throughout interphase & the endoplasmic reticulum during metaphase (putative)

More general terms

• phosphoprotein
• membrane protein
• nuclear protein

Component of

• nuclear pore complex (NPC)

Database

• UniProt: http://www.uniprot.org/uniprot/A8CG34.html