nuclear envelope pore membrane protein POM 121; pore membrane protein of 121 kDa; nuclear envelope pore membrane protein POM 121A (POM121 KIAA0618 NUP121 POM121A)

Function

• component of the nuclear pore complex
• repeat-containing domain may be involved in anchoring components of the nuclear pore complex to the pore membrane
• when overexpressed in cells induces the formation of cytoplasmic annulate lamellae

Structure

• belongs to the POM121 family
• contains F-X-F-G repeats

Compartment

• nuclear pore complex, endoplasmic reticulum membrane
• stably associated with the nuclear pore complex throughout interphase & endoplasmic reticulum during metaphase

Alternative splicing

named isoforms=3

More general terms

• nucleoporin (nuclear pore complex protein)
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9883
• UniProt: http://www.uniprot.org/uniprot/Q96HA1.html