pyrin domain-containing protein 2; pyrin-only protein 2 (PYDC2 POP2)

Function

• inhibits NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA
• disrupts the interaction between PYCARD & NLRP3
• interacts with PYCARD/ASC

Structure

contains 1 DAPIN domain

Compartment

cytoplasm. nucleus

Expression

• predominantly expressed in peripheral blood
• weakly expressed in testis

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1521
• UniProt: http://www.uniprot.org/uniprot/Q56P42.html