criteria for diagnosis of polycythemia vera
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Diagnostic criteria
- elevated red cell mass (erythrocytosis)
- normal arterial oxygen saturation
- splenomegaly
- in the absence of splenomegaly, leukocytosis & thrombocytosis
- plasma erythropoietin level < 4 mU/mL
- JAK2 V617F mutation[2][3]*
*proposed diagnostic criteria would allow diagnosis of JAK2 V617F mutation-associated disorders without a bone marrow biopsy[2]
More general terms
Additional terms
References
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 680
- ↑ 2.0 2.1 2.2 Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
- ↑ 3.0 3.1 Vainchenker W and Constantinescu SN Hematology Am Soc Hematol Educ Program. 2005:195-200. A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/16304380 <Internet> http://asheducationbook.hematologylibrary.org/cgi/content/full/2005/1/195