CD99 antigen-like protein 2 (MIC2-like protein 1, CD99L2, MIC2L1, UNQ1964/PRO4486)

Function

• may function as a homophilic adhesion molecule
• functions in leukocyte-endothelial cell interactions during leukocyte extravasation, & in particular, at the diapedesis step
• does not seem to be involved in docking of leukocytes to the vessel wall or in lymphocyte diapedesis (putative)
• O-glycosylated (putative)

Structure

belongs to the CD99 family

Compartment

• cell membrane, extracellular side
• cell junction

Alternative splicing

named isoforms=4

Expression

• expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle, ovary, thymus, testis & uterus. lower expression seen in thymus
• expressed in E18 uterus & placenta

More general terms

• membrane protein
• adhesion protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8369
• UniProt: http://www.uniprot.org/uniprot/Q8TCZ2.html