Ca+2-activated chloride channel regulator 4; Ca+2-activated chloride channel family member 4; hCLCA4; Ca+2-activated chloride channel protein 2; CaCC-2; hCaCC-2; contains: Ca+2-activated chloride channel regulator 4, 110 kD form, Ca+2-activated chloride channel regulator 4, 30 kD form (CLCA4, CaCC2, UNQ562/PRO1124)

Function

• may be involved in mediating Ca+2-activated chloride conductance
• processed at a monobasic residue to yield a larger N-terminal & a smaller C-terminal cleavage products of 90 to 110 & 30 to 35 kD, respectively (putative)

Structure

• N-glycosylated (putative)
• belongs to the CLCR family
• contains 1 VWFA domain

Compartment

• cell membrane
• apical cell membrane
• secreted (putative)
• the C-terminus 30 kD form is anchored to the membrane (putative)
• the N-terminus 110 kD form is released from the membrane triggered by an unknown stimulus

Expression

• primarily expressed in the digestive tract, mainly in colon
• detected in smaller amounts in brain, urogenital organs, testis, & salivary & mammary glands
• highly expressed in the epithelial layer & submucosal gland of the inferior turbinate mucosa
• lower levels in the epithelial layer of nasal polyp

Pathology

• down-regulated in oral tongue squamous cell carcinomas

More general terms

• glycoprotein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2280
• UniProt: http://www.uniprot.org/uniprot/Q14CN2.html