chymotrypsin-C; caldecrin (CTRC, CLCR)

Function

• chymotrypsin-type protease activity & hypocalcemic activity
• preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa

Structure

• belongs to the peptidase S1 family, elastase subfamily
• contains 1 peptidase S1 domain

Expression

pancreas

Pathology

• genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity

More general terms

• chymotrypsin (alpha chymotrypsin)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11330
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11330
• OMIM: https://mirror.omim.org/entry/601405
• UniProt: http://www.uniprot.org/uniprot/Q99895.html