seizure protein 6 homolog (SEZ-6, hSEZ-6, SEZ6)

Function

• may play a role in cell-cell recognition & in neuronal membrane signaling
• role in balance between dendrite elongation & branching during the elaboration of a complex dendritic arbor (putative)
• role in development of appropriate excitatory synaptic connectivity

Structure

• glycosylated (putative)
• belongs to the SEZ6 family
• contains 2 CUB domains
• contains 5 Sushi (CCP/SCR) domains

Compartment

• cell membrane; (putative)
• localized on dendrites & in the synaptic & postsynaptic fraction (putative)

Alternative splicing

named isoforms=4

Pathology

• genetic variations in SEZ6 may be involved in susceptibility to febrile convulsion

More general terms

• phosphoprotein
• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q53EL9.html