retrotransposon-like protein 1 (retrotransposon-derived protein PEG11, paternally expressed gene 11 protein, mammalian retrotransposon derived protein 1, RTL1, MAR1, MART1, PEG11)

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Function

plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface & for development of the placenta (putative)

membrane (putative)

excessive RTL1 expression & decreased RTL1 expression are relevant to upd(14)pat-like & upd(14)mat-like phenotypes, respectively

Rtl1 is one of at least 11 genes called mar or mart related to long terminal repeat retrotransposons
they do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes
RTL1 is an imprinted gene located in a cluster of imprinted genes on chromosome 14
it is expressed from the paternal chromosome & has an antisense transcript with full complementarity to RTL1, RTL1as, expressed from the maternal chromosome, which acts as a repressor for RTL1