histone H1oo (oocyte-specific histone H1, oocyte-specific linker histone H1, osH1, H1FOO, H1OO, OSH1)

Function

• may play a key role in the control of gene expression during oogenesis & early embryogenesis, presumably through the perturbation of chromatin structure
• essential for meiotic maturation of germinal vesicle-stage oocytes
• the somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte
• the greater mobility of H1oo as compared to H1c may contribute to this rapid replacement & increased instability of the embryonic chromatin structure
• the rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (putative)

Structure

belongs to the histone H1/H5 family

Compartment

cytoplasm (putative). nucleus

Alternative splicing

named isoforms=2

Expression

oocyte-specific

More general terms

• histone-H1

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1322
• UniProt: http://www.uniprot.org/uniprot/Q8IZA3.html