host cell factor C1 regulator 1 (HCF-1 beta-propeller-interacting protein, HCFC1R1, HPIP)

Function

• regulates HCFC1 activity by modulating its subcellular localization
• overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm
• HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus
• interacts with HCFC1

Compartment

• cytoplasm, nucleus
• shuttles between the nucleus & cytoplasm (CRM1-dependent)

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NWW0.html