plasminogen activator inhibitor-1 genotyping

Clinical significance

• plasminogen activator inhibitor-1
  • major inhibitor of fibrinolysis
  • when increased, fibrinolytic activity is diminished with increased risk of
    • arterial thrombosis
    • venous thrombosis
  • increased activity is an independent risk factor for
    • coronary artery disease
    • ischemic stroke
    • venous thrombosis
    • osteonecrosis

Specimen

• whole blood

More general terms

• genotyping (allele testing)