glutathione S-transferase theta-2B (GSTT2B)

Function

• conjugation of reduced glutathione to a wide number of exogenous & endogenous hydrophobic electrophiles
• has a sulfatase activity

RX + glutathione = HX + R-S-glutathione

Structure

• belongs to the GST superfamily, theta family
• contains 1 GST C-terminal domain
• contains 1 GST N-terminal domain

Compartment

cytoplasm

Expression

• expressed at low levels in liver
• in lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages & alveolar type-2 cells

More general terms

• glutathione transferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2953
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=653689
• UniProt: http://www.uniprot.org/uniprot/P0CG30.html