triclosan (Irgasan, Cloxifenolum, Triclosanum, Cliniclean, Cloxifenol, Tersaseptic, Aquasept, Manusept, Sapoderm)
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Uses
- used in cosmetics & toilet soaps as an antiseptic
Adverse effects
- muscle weakness in mice[3]
- triclosan induces antibiotic tolerance in Escherichia coli & S aureus[4]
- antibiotic resistance to kanamycin, streptomycin, ciprofloxacin, ampicillin, vancomycin is substantial[4]
Mechanism of action
- antiseptic
- has some bacteriostatic & fungistatic action
- inhibits fatty acid synthase
More general terms
Component of
- sodium fluoride/toothpaste/triclosan
- triclosan/undecylenate
- sodium fluoride/triclosan
- miconazole/triclosan
- ethanol/triclosan
- chloroxylenol/triclosan
- benzocaine/triclosan
References
- ↑ PubChem: 5564
- ↑ FDA News Release, April 8, 2010 FDA Provides Information to Consumers about the Ingredient Triclosan http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm207833.htm
FDA Consumer Update Triclosan: What Consumers Should Know http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm205999.htm
APRIL 8, 2010: MARKEY URGES BAN ON ANTIMICROBIAL CHEMICAL IN CONSUMER SOAPS, FOLLOWING FDA CONCERNS http://markey.house.gov/index.php?option=content&task=view&id=3964&Itemid=125 - ↑ 3.0 3.1 Cherednichenko G et al Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. PNAS August 13, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22891308 <Internet> http://www.pnas.org/content/early/2012/08/08/1211314109.abstract#aff-1
- ↑ 4.0 4.1 4.2 Westfall C, Flores-Mireles AL, Robinson JI et al. The widely used antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo Antimicrob Agents Chemother 2019 Apr 25; 63:5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30782996 Free full text https://aac.asm.org/content/63/5/e02312-18