hypertrophic osteoarthropathy

Etiology

• primary hypertrophic osteoarthropathy (idiopathic)
• hypertrophic pulmonary osteoarthropathy
  • cystic fibrosis
• patent ductus arteriosus
• Crohn's disease
• myelofibrosis
• carcinoma, paraneoplastic syndrome

Pathology

• neoangiogenesis & edema & osteoblast proliferation in distal tubular bones leading to subperiosteal new-bone formation
• excessive proliferation of skin & bone at distal parts of the extremities

Clinical manifestations

• oligo or polyarthritis
  • symmetrical arthralgias
  • large joint involvement (knees, elbows, ankles, wrists)
  • synovial effusions, pitting edema
• digital clubbing
• painful periostosis of the long bones
• alleviation of pain by elevating affected extremities

Radiology

• chest X-ray for hypertrophic pulmonary osteoarthropathy
• chest CT for lung carcinoma

More general terms

• osteoarthropathy

More specific terms

• hypertrophic pulmonary osteoarthropathy (Bamberger-Marie syndrome)
• primary hypertrophic osteoarthropathy (pachydermoperiostosis)