cytochrome P450 2E1 (ethanol-inducible cytochrome P450, CYP2E1)

Function

• metabolizes several procarcinogens, drugs, & solvents to reactive metabolites
  • involved in metabolism of nitrosamines
• inducers
  • ethanol
  • isoniazid
• substrates
  • eszopiclone
  • isoniazid

Compartment

membrane-bound, endoplasmic reticulum

Expression

induced by ethanol & isoniazid

More general terms

• cytochrome P450

Database

• UniProt: http://www.uniprot.org/uniprot/P05181.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1571
• OMIM: https://mirror.omim.org/entry/124040
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1571