methemoglobin (MetHb, Hi)

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Introduction

Hemoglobin with oxidized or ferric heme (Fe+3). Normal methemoglobin content of erythrocytes is < 1-1.5%. A small amount of methemoglobin is always being produced, but is reduced back to hemoglobin by the NADH methemoglobin reducatase system (largely NADH cytochrome-b5 reductase & to a lesser extent ascorbate, glutathione & NADPH methemoglobin reductase). Methemoglobin combines strongly with cyanide, sulfide, peroxides, fluoride, & azide.

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References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 791
  2. Henry's Clinical Diagnosis & Management by Laboratory Methods, 21st edition, McPherson RA & Pincus MR (es), W.B. Saunders Co., Philadelphia, PA. 2007, 457