endogenous retroviral GAG polyprotein
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Introduction
Endogenous retroviral proteins may have kept, lost or modified their original function during evolution. Retroviral GAG proteins function in assembly, budding, maturation, & infection stages of the viral replication cycle.
Function
- contains regions homologous to matrix, capsid & nucleocapsid proteins from infectious retroviruses
- can be cleaved into mature proteins homologous to retroviral matrix protein
- myristoylation is essential for retroviral assembly
- synthesized as Gag polypeptide & as Gag-Pro-Pol polyprotein
More general terms
More specific terms
- HERV-K 12q14.1 provirus ancestral Gag polyprotein ([Contains: Matrix protein; Capsid protein; Nucleocapsid protein])
- HERV-K 19p13.11 provirus ancestral Gag polyprotein (HERV-K113 Gag protein, [Contains: Matrix protein; Capsid protein; Nucleocapsid protein])
- HERV-K 19q12 provirus ancestral Gag polyprotein (HERV-K(C19) Gag protein, [Contains: Matrix protein; Capsid protein; Nucleocapsid protein])
- HERV-K 1q22 provirus ancestral Gag polyprotein; HERV-K102 Gag protein; HERV-K(III) Gag protein [Contains: matrix protein; capsid protein; nucleocapsid protein]
- HERV-K 22q11.21 provirus ancestral Gag polyprotein (HERV-K101 Gag protein, [Contains: Matrix protein; Capsid protein; Nucleocapsid protein])
- HERV-K 3q12.3 provirus ancestral Gag polyprotein (HERV-K(II) Gag protein, [Contains: Matrix protein; Capsid protein; Nucleocapsid protein], ERVK5)
- HERV-K 6q14.1 provirus ancestral Gag polyprotein (HERV-K109 Gag protein, HERV-K(C6) Gag protein, [Contains: Matrix protein; Capsid protein; Nucleocapsid protein])
- HERV-K 7p22.1 provirus ancestral Gag polyprotein; HERV-K(HML-2.HOM) Gag protein; HERV-K108 Gag protein; HERV-K(C7) Gag protein [Contains: matrix protein; capsid protein; nucleocapsid protein] (ERVK6)
- HERV-K 8p23.1 provirus ancestral Gag polyprotein; HERV-K115 Gag protein [Contains: matrix protein; capsid protein; nucleocapsid protein]