methylcobalamin (vitamin B12)

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Introduction

Methylcobalamin the cofactor of methionine synthase (homocysteine methyltransferase, a methylcobalamin & N5-methyltetrahydrofolate- dependent enzyme.

In connection with 5,10 methylenetetrahydrofolate reductase activity which generates 5-methyltetrahydrofolate, methionine synthase regulates methionine synthesis & tetrahydrofolate generation. The availability of tetrahydrofolate is critical to DNA & RNA generation.

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References

  1. Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 582
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 2200

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