methylmalonyl coenzyme A

Introduction

Methylmalonyl-CoA is formed from propionyl CoA in a reaction catalyzed by propionyl CoA carboxylase.

Methylmalonyl-CoA feeds into the citric acid cycle via conversion to succinyl CoA catalyzed by methylmalonyl CoA mutase, one of 2 mammalian enzymes using vitamin B12 as a cofactor.

More general terms

• acyl Coenzyme A

Additional terms

• coenzyme A
• methylmalonate; methylmalonic acid (MMA)
• methylmalonyl CoA carboxylase
• propionate (propanoate)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=123909
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=439754
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=613