2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
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Introduction
Mutagen from cooked meats, formed from condensation of l-phenylalanine + creatine + heat
More general terms
References
- ↑ Qiu C, Shan L, Yu M, Snyderwine EG. Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine. Carcinogenesis. 2005 Apr;26(4):763-9. Epub 2005 Jan 6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15637090
- ↑ Shan L, Yu M, Schut HA, Snyderwine EG. Susceptibility of rats to mammary gland carcinogenesis by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) varies with age and is associated with the induction of differential gene expression. Am J Pathol. 2004 Jul;165(1):191-202. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15215175
- ↑ Snyderwine EG, Venugopal M, Yu M. Mammary gland carcinogenesis by food-derived heterocyclic amines and studies on the mechanisms of carcinogenesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutat Res. 2002 Sep 30;506-507:145-52. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12351154