teicoplanin

Dosage

• 6 mg/kg/day

Dosage adjustment in renal failure

Table

creatinine clearance	dosage
> 50-90 mL/min	24 hour dosing
10-50 mL/min*	48 hour dosing
< 10 mL/min#	72 hour dosing

* same dose for continuous arteriovenous hemofiltration

# same dose for hemodialysis

Pharmacokinetics

• 1/2life 45 hours (62-230 hours ESRD)

1/2life = 32-130 hours

protein binding = 88-91 %

elimination by hemodialysis = -

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
  • Streptococcus pneumonia
• Enterococcus faecalis
• Enterococcus faecium (+/-)
• Staphylococcus aureus (MSSA)
• Staphylococcus aureus (MRSA)
• Staphylococcus epidermidis (+/-)

Anaerobes

• Clostridium difficile (+/-)
• Clostridium species

Drug interactions

• teicoplanin & aminoglycosides are incompatible in solution

• drug interaction(s) anticonvulsants with anti-bacterial agents
• drug interaction(s) of antibiotics with warfarin

Laboratory

• specimen:
  • serum urine
  • stable for 1 year at -20 degrees C
• methods:
  • serum: bioassay, SPERA, RASA, FPIA, HPLC
  • urine: bioassay, SPERA, HPLC
• interferences:
  • lysed erythrocytes & presence of other antibiotics interfere with bioassay

Mechanism of action

• mixture of 6 glycopeptides

More general terms

• antibacterial glycopeptide