cefonicid (Monocid)

Introduction

Tradename: Monocid. 2nd generation cephalosporin.

Indications

• treatment of bacterial infections due to susceptible organisms
  • lower respiratory tract infection
    • pneumonia
  • skin or soft tissue infection
  • infectious arthritis, osteomyelitis
• prophylaxis for perioperative infection
  • prosthetic arthroplasty

Dosage

1-2 g IV/IM every 24 hours

Antimicrobial activity

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
  • Streptococcus pneumonia
  • Streptococcus viridans, milleri
• Staphylococcus aureus (MSSA)
• Staphylococcus epidermidis (+/-)

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Moraxella catarrhalis
• Haemophilus influenzae
• Escherichia coli
• Klebsiella species
• Enterobacter species
• Proteus mirabilis
• Proteus vulgaris
• Providencia species
• Morganella species
  • Morganella morganii
• Citrobacter species (+/-)
• Aeromonas species (+/-)

Anaerobes

• Clostridium species
• Peptostreptococcus species

More general terms

• cephalosporin, 2nd generation

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441391
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=166591
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=44187
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=43594
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=43592