cefprozil (Cefzil)

Introduction

Tradename: Cefzil. 2nd generation cephalosporin.

Indications

• treatment of bacterial infections due to susceptible organisms
  • acute otitis media
  • upper respiratory tract infections
    • tonsillitis
  • bronchitis
  • skin or soft tissue infection
• empiric treatment of fever of unknown origin

Dosage

250-500 mg PO QD or divided BID

Tabs: 250, 500 mg, Suspension: 125, 250 mg/5 mL.

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
• Streptococcus pneumonia
• Staphylococcus aureus (MSSA)
• Staphylococcus epidermidis (+/-)

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Moraxella catarrhalis
• Haemophilus influenzae
• Escherichia coli
• Klebsiella species
• Salmonella species
• Shigella species
• Proteus mirabilis

Anaerobes

• Bacteroides melaninogenicus
• Clostridium species
• Peptostreptococcus species

More general terms

• cephalosporin, 2nd generation

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=52810006
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=92088
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=62977
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5284528
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2646