aurothioglucose [gold] (Solganal)

Introduction

Tradename: Solganal. [[[A19056|gold]]]. Rheumatoid arthritis: starting dose: 10 mg IM weekly. average dose: 50 mg IM monthly If no improvement after 1 g, reassess use of gold.

Pharmacokinetics

• gold content is 50%
• elimination 1/2 life varies with dose
• 70% excreted in urine, 30% in feces

elimination via kidney

elimination via feces

1/2life = 3-27 days

protein binding = 99 %

Adverse effects

• rash, may be localized

Toxicity: may be manifested by eosinophilia.

Drug interactions

• may increase phenytoin levels

Mechanism of action

• supresses of prevents arthritis & synovitis
• taken up by macrophages resulting in inhibition of phagocytosis & perhaps lysosomal activity
• decreases serum levels of rheumatoid factor & immunoglobulins
• may decrease synovial inflammation & retard cartilage & bone destruction

More general terms

• disease-modifying antirheumatic agent (DMARD)

Additional terms

• gold [Au]

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6104
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3032577
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=454937