benzoyl peroxide (Panoxyl, Theraderm, Acetoxyl, Asidopan, Persadox, Benoxyl, Lucidol, Mytolac, Oxylite)

Introduction

Tradename: Panoxyl.

Indications

• adjunctive treatment of mild to moderate:
  • acne vulgaris
  • acne rosacea

Contraindications

• pregnancy category: C

Dosage

• wash: QD-BID
• topical: apply sparingly QD initially, the gradually increase to BID-TID PRN

Solution: 2.5%, 4%, 5%, 10%. 1.5 oz.

Adverse effects

• many preparations are drying to skin
• initial facial redness & irritation which resolves with continuous use
• contact dermatitis
• dryness & peeling

Mechanism of action

• releases active oxygen radicals resulting in a decrease in the number of anaerobic bacteria
• bactericidal & keratolytic

More general terms

• peroxide
• dermatologic agent

Component of

• benzoyl peroxide/doxycycline
• benzoyl peroxide/salicylic acid/sulfur
• benzoyl peroxide/hyaluronate based injectable gel
• benzoyl peroxide/emollient/salicylic acid
• benzoyl peroxide/clindamycin/phosphate
• benzoyl peroxide/salicylic acid
• benzoyl peroxide/hyaluronate
• benzoyl peroxide/cortisol
• benzoyl peroxide/sulfur
• benzoyl peroxide/erythromycin (Benzamycin)
• benzoyl peroxide/tretinoin (Benzashave)
• benzoyl peroxide/clindamycin (BenzaClin)
• adapalene/benzoyl peroxide (Epiduo)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=7187